Hydroxyzine pamoate and hydroxyzine HCl both deliver the same active drug, hydroxyzine, so their clinical effects (such as sedation, itch relief, and anxiety reduction) are broadly similar. Hydroxyzine is used to help control anxiety and tension caused by nervous and emotional conditions. It can also be used to help control anxiety and produce sleep before surgery. Hydroxyzine is used for the short-term treatment of nervousness and tension that may occur with certain mental/mood disorders. Learn about side effects, drug interactions, dosages, warnings, and more. Learn what hydroxyzine HCl 10 mg treats, how fast it works, and what side effects to watch for, including heart and age-related considerations. Hydroxyzine, sold under the brand names Atarax (as hydrochloride) and Vistaril (as pamoate) among others, is an antihistamine medication. It is used in the treatment of itchiness, anxiety, insomnia, and nausea (including that due to motion sickness). Overview: Hydroxyzine is an antihistamine that is used for certain types of anxiety, itching due to allergic conditions, to help you relax before and after general anesthesia, or for nausea and. Hydroxyzine, a common anti-anxiety and antihistamine prescription medication, comes in two forms: hydrochloride (HCl) and pamoate. They both contain the same active drug, but they have different salt forms (pamoate vs. hydrochloride). Hydroxyzine is sold under the brand names Atarax or Vistaril. It is used as an antihistamine to help reduce the occurrence of sneezing or runny nose. Unlike some antihistamines you can use this drug to treat allergic reactions on the skin, such as hives or contact dermatitis. Hydroxyzine is an antihistamine used to treat allergy symptoms and more. Learn how to use hydroxyzine for anxiety, its dosage, and potential side effects. Hydroxyzine is a prescription antihistamine used to treat anxiety and tension, itching from allergic skin conditions, and sedation before and after general anesthesia. It comes in three oral forms: There is also a hydroxyzine hydrochloride injection.